Biochem/physiol Actions

Primary Targetcathepsin L

Reversible: yes

Product does not compete with ATP.

Target IC₅₀: 1.9 nM against Cathepsin L

Cell permeable: yes

General description

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Inhibits the release of Ca²⁺ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Also inhibits the release of Ca²⁺ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

Packaging

1 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

1-Naphthalenesulfonyl-Ile-Trp-CHO

Warning

Toxicity: Standard Handling (A)